The Master Plan will be a comprehensive look at the places and spaces in and adjacent to the Innovation District. It will include discussions of zoning, infrastructure, public spaces, types of buildings, facility uses, programming and more.

The District was formed in 2016, and early planning efforts included a strategic plan and a placemaking and streetscape design. As the District has evolved, so has the land and its uses. The 2019 Employment Center-2 (EC-2) zoning designation in the northern part of the District created the opportunity for pedestrian oriented amenities, neighborhood scale cafes, and expanded use of office space, for example The Library Restaurant.  The adaptive reuse of a building on the Port of St. Pete inspired a co-working space for technology small businesses called the Maritime and Defense Technology Hub.